What Professionals Say
NoBS. NMN (Nicotinamide Mononucleotide)
David Sinclair has been a major advocate for NMN and its potential to support healthy aging. In his work, he emphasizes that NAD+ is a vital molecule involved in energy production, DNA repair, and cellular health, but its levels naturally decline with age. Sinclair believes that NMN is one of the most effective NAD+ precursors that can help replenish NAD+ levels, potentially reversing some aspects of aging.
What Sinclair says: In his book Lifespan, Sinclair discusses how NMN can boost NAD+ levels in cells, which may lead to improvements in metabolic function, muscle performance, and overall healthspan (the period of life spent in good health). Scientific backing: Sinclair and his team have conducted research in mice showing that increasing NAD+ levels using NMN can improve mitochondrial function, extend lifespan, and help mitigate age-related diseases.
Personal use: Sinclair has openly mentioned that he personally takes NMN as part of his daily regimen in an effort to maintain vitality and promote longevity.
NoBS. Resveratrol
Sinclair has been one of the leading proponents of Resveratrol as a compound that can activate sirtuins, a family of proteins that regulate cellular health, metabolism, and longevity.
What Sinclair says: Sinclair has studied Resveratrol as a potential activator of sirtuins, particularly SIRT1, which is associated with longevity and DNA repair. By activating these proteins, Sinclair believes that Resveratrol may have a protective effect against age-related conditions and promote better metabolic health.
Scientific backing: In studies, Resveratrol has been shown to have antioxidant and anti-inflammatory effects, which may help protect cells from damage. Sinclair and other researchers have looked at how Resveratrol mimics the benefits of caloric restriction, a well-known method for extending lifespan in various organisms.
Resveratrol’s role: Sinclair suggests that while Resveratrol is not a magic bullet, it may play a supportive role in promoting longevity when combined with other lifestyle factors like exercise and a healthy diet.
NoBS. Grapeseed Extract
While Sinclair does not discuss Grapeseed Extract in as much detail as NMN and Resveratrol, he is a strong advocate for antioxidants as part of a broader strategy to protect cells from damage and aging. Since Grapeseed Extract is known for its high antioxidant content, it aligns with Sinclair's general approach to using compounds that support cellular health and longevity.
Summary of Sinclair's Views
Sinclair emphasizes that aging is not an inevitable process, and that through strategic use of supplements like NMN, Resveratrol, and other natural compounds, combined with a healthy lifestyle, we can extend our healthspan and improve our quality of life as we age. However, he also stresses that more research is needed to fully understand the long-term effects of these compounds in humans.
Resveratrol
He advocates for Resveratrol as an activator of sirtuins, which may support DNA repair, metabolic function, and cellular health. While its benefits are still under research, Sinclair believes it may mimic the effects of caloric restriction and offer protective effects against aging.
NMN
Sinclair sees NMN as a powerful NAD+ booster that may help improve cellular health, energy, and longevity. His research indicates that NMN could play a key role in reversing some aspects of aging.
Grapeseed Extract
While Sinclair does not focus on Grapeseed Extract as much as NMN or Resveratrol, its antioxidant properties are in line with his general belief in using antioxidants to fight oxidative stress and maintain youthful health.