What Professionals Say
NoBS. NMN (Nicotinamide Mononucleotide)
Dr. Guarente is one of the leading advocates for NMN as a powerful NAD+ booster. Guarente has researched how increasing NAD+ levels can slow down the aging process and improve cellular health.
What Guarente says: Guarente has highlighted NMN as one of the most effective precursors to NAD+, which can boost NAD+ levels in the body and improve mitochondrial function. His research suggests that NMN supplementation could potentially extend lifespan and improve healthspan by promoting DNA repair, reducing inflammation, and enhancing energy production at the cellular level.
Scientific backing: Guarente’s work with NAD+ has shown that NMN can be effectively converted into NAD+ in cells, which may have far-reaching effects on aging and age-related diseases. His research has focused on how this increase in NAD+ can activate sirtuins, proteins that are involved in regulating metabolism and longevity.
Guarente’s stance: Guarente believes that increasing NAD+ levels through NMN supplementation could have significant anti-aging benefits, and he considers it one of the key pathways for promoting healthy aging.
NoBS. Resveratrol
Dr. Guarente has conducted significant research on Resveratrol and its potential to activate sirtuins, particularly SIRT1, which is known to be involved in regulating processes like DNA repair, metabolism, and longevity.
What Guarente says: Guarente has been a strong advocate for Resveratrol, especially in relation to its potential to activate SIRT1. Resveratrol mimics the effects of caloric restriction, which has been shown to extend lifespan in various organisms. By activating SIRT1, Resveratrol helps enhance the function of mitochondria, regulate insulin sensitivity, and promote DNA repair.
Scientific backing: Guarente’s research has shown that Resveratrol can indeed activate SIRT1, leading to improvements in cellular function, metabolism, and longevity. Guarente has pointed out that the benefits of Resveratrol in humans are still being studied, though preliminary data is promising.
Guarente’s stance: Dr. Guarente supports Resveratrol as a supplement that can help activate sirtuins and support longevity. He sees it as an important tool in the broader strategy of promoting healthspan and potentially slowing down aging.
NoBS. Grapeseed Extract
Dr. Guarente has not specifically focused on Grapeseed Extract in his published work as much as he has on NMN and Resveratrol, but he does acknowledge the importance of antioxidants and anti-inflammatory compounds in promoting healthy aging.
Summary of Guarente's Views
Dr. Guarente’s overall philosophy focuses on the importance of NAD+ and sirtuins in combating aging. He supports the use of NMN and Resveratrol as part of a strategy to optimize longevity, and while he does not emphasize Grapeseed Extract as much, he acknowledges antioxidents as a helpful addition to an anti-aging regimen.
Resveratrol
Guarente supports Resveratrol for its ability to activate sirtuins, particularly SIRT1, which can improve cellular health, promote DNA repair, and support longevity. He emphasizes its role in mimicking caloric restriction and extending lifespan.
NMN
Guarente views NMN as a key supplement for boosting NAD+ levels, which has the potential to improve mitochondrial function, energy production, and promote healthy aging. He believes it is one of the most promising tools in extending healthspan and potentially reversing some aspects of aging.